Pharmacogenomics and the Treatment of Depression
About half of the people who take antidepressants do not respond -- and many patients experience adverse effects. These outcomes may be partially attributed to the impact of an individual’s genetic profile. Understanding the neurobiology of depression and using a pharmacogenomic decision-support tool, clinicians could provide personalized healthcare designed to improve antidepressant therapy outcomes. In this presentation, the evidence, evolution, and current state of antidepressant pharmacogenetic decision support tools are reviewed. A series of considerations for clinicians contemplating the use of these tools is presented in the context of contemporary NP practice.
Credits: 1.00 contact hours; 1.00 are pharmacology
As a result of this activity, the learner will be able to:
- Conceptualize mental illness in the context of epi/genetics and neurobiology, with an emphasis on depressive disorders.
- Discuss contemporary approaches to the management of depressive disorders, including practical applications for nurse practitioners.
- Apply concepts of pharmacogenomics to the selection, prescription, and management of drug therapy for disorders of depressed mood.
Josh Hamilton, DNP, RN-BC, FNP-C, PMHNP-BC, CTMH, CNE, FAANP
President & Chief Clinical Officer
The Hamilton Group LLC
Dr. Josh Hamilton bases his clinical practice in Las Vegas, NV. With more than two decades of nursing experience, he also holds professorial appointments, leadership positions and consults extensively in the higher education space. Previously, he was Associate Medical Director for the largest managed care behavioral health network in the Desert Southwest. He served on the Nevada Board of Nursing’s Advanced Practice and Educational Advisory Committees and spearheaded the Donate Life campaign at the state level.
His professional interests include neurobiology, pharmacology and epigenetics. He is an internationally-recognized speaker on these (and related) topics at conferences and professional meetings. He works with a variety of organizations to develop, review and present live and enduring continuing education activities. Engagements include the American Association of Nurse Practitioners, Myriad Neuroscience, MedIQ, Nurse Practitioner Continuing Education Associates (NPACE), and Vindico Medical Education. He serves on the psychiatric medication working group at the Center of Excellence in Regulatory Science & Innovation, a FDA-sponsored project at the University of Maryland.
Dr. Hamilton earned his doctorate in nursing from Rush University in Chicago. At the University of Wyoming, he earned a baccalaureate degree in Natural Science and Mathematics as well as a master’s degree in Nursing. He also has an undergraduate degree in Biology. He is nationally certified as a psychiatric-mental health nurse; family nurse practitioner; family psychiatric nurse practitioner, telemental healthcare provider, and nurse educator. He was recognized as a doctoral scholar by the National League for Nursing, and he is a fellow of the American Association of Nurse Practitioners. He was recognized for establishing a unique clinic structure that improves access to cost-effective, convenient, quality mental healthcare. His academic connections fostered synergies and renewed attention to nursing education that focuses on care for the vulnerable mentally ill population in Nevada and across the nation. Dr. Hamilton is also a master clinical psychopharmacologist (through the Neuroscience Education Institute), and he was the 2015 Distinguished Alumnus at his alma mater, the University of Wyoming. He is the Nevada state representative for AANP.
A classically trained pianist, Dr. Hamilton enjoys live music, international travel and automobiles. He is an active supporter of local animal rescue and rehoming efforts, as well as charities that provide critical transportation for patients in need of distant life-saving specialty healthcare. Dr. Hamilton grew up in Casper, Wyoming, with his sights set on medical school. He originally pursued a nursing degree thinking the experience would make him a better physician. Along the way, he discovered an affinity and passion for the humanistic, health-promoting philosophy of nursing. He has since devoted his career to clinical practice, furthering the cause of the profession and educating future leaders in the healthcare field.
Learn more about Dr. Josh Hamilton at www.linkedin.com/in/hamiltondnp
Obtain Your Credits
To earn credits for this activity, you must complete all course components in the following order: 1) complete a three-question pre-test; 2) watch the course presentation video; 3) complete the course evaluation; 4) pass the post-test with a score of 2/3 (66.7%) or higher. You may retake the post-test until a passing score is achieved, at which point you will be able to view/print a copy of your certificate of completion. This online certificate will also be saved within your profile dashboard transcript for future access.
NPACE designates this educational activity for a maximum of 1.00 contact hours, of which 1.00 is pharmacology credit. Participants should claim only credit commensurate with the extent of their participation in the activity.
Nurse Practitioner Associates for Continuing Education (NPACE) is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation (ANCC).
In addition to ANCC, NPACE is approved as a provider of continuing education in nursing by: the California Board of Registered Nursing, Provider Number CEP8720 and Florida CE Broker #50-1476.
Contributing faculty, Josh Hamilton, DNP, RN-BC, FNP-C, PMHNP-BC, CNE, FAANP, have disclosed the following relevant financial relationships; Speaker's Bureau for Myriad Genetics.
All planners and contributors involved in this educational activity have disclosed no relevant financial relationships.
The material presented in this continuing education program is being made available for educational purposes only and is not intended to represent the best or only methods, medications and/or guidelines appropriate for the medical situation discussed. Rather the material is intended to present an approach, view, statement, or opinion of the presenter(s), which may be helpful, or of interest to other practitioners and should not be used by clinicians without the evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. NPACE disclaims any liability, loss, injury, or damage incurred as a consequence, directly or indirectly, of the use and application of any information given in a presentation.
Disclosure of Unlabeled Use
This educational activity may mention the uses of products that are not approved by the FDA for the indication(s) being discussed. The presenter(s) are instructed to notify participants when they are discussing unapproved uses or investigational agents. The opinions related to unapproved uses of products are solely those of the presenter(s) and are not endorsed or recommended by NPACE. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
There is no commercial support for this activity.
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